Journal article
Synthesis and antioxidant capacity of novel stable 5-tellurofuranose derivatives
EL Borges, MT Ignasiak, Y Velichenko, G Perin, CA Hutton, MJ Davies, CH Schiesser
Chemical Communications | ROYAL SOC CHEMISTRY | Published : 2018
DOI: 10.1039/c8cc00565f
Abstract
Novel stable tellurium-containing carbohydrate derivatives are prepared from hexitols and pentitols through a double nucleophilic substitution with NaHTe in PEG-400. These tellurosugars react at very high rates with two-electron oxidants, including hypochlorous and peroxynitrous acid, formed at sites of inflammation, and show considerable promise as protective agents against oxidative damage.
Grants
Awarded by Australian Research Council
Funding Acknowledgements
We thank the Australian Research Council through the Centres of Excellence Scheme, the University of Melbourne through the International Research and Research Training fund (IRRTF), the Novo Nordisk Foundation (grants: NNF13OC0004294 and NNF15OC0018300) for financial support, and CNPq (Brazil) for scholarships and research fellowships granted to ELB and GP.